Dr. Guang-Yu Li is Chief Physician, Professor and Ph.D Supervisor of Ophthalmology. He is also Vice Dean of Ophthalmology Center, Second Hospital of JiLin University. In 2000, he received his Master Degree at the Norman Bethune Medical University and started his clinic work at Second Hospital of JiLin University. From 2006 to 2008, he worked as Postdoctoral Fellow at Oxford University in UK and in 2009, he cooperated with Prof. Thanos as a Visiting Scholar at Minster University in Germany.
His major clinic area covers orbital disease, eyelid disease and lacrimal disease, including orbital fracture, orbital tumor, TAO, ptosis, eyelid tumor, dacryocystitis, lacrimal obstruction etc. From 2014, he becomes a member of Association of Traditional Chinese Medicine and Western Medicine. His main aim of scientific research is to decipher molecular mechanisms in ocular neurodegenerative diseases and realize neuroprotection and regeneration. Dr. Guang-Yu Li is a peer reviewer of following international journals: Medical Hypotheses, Food and Chemical Toxicology, Molecules, and Molecular Vision. He is also a reviewer of National Scientific Foundation. So far, he has got over 30 publications and eighteen of them were indexed by SCI. From 2010, he has been awarded the Natural Science Prize of JiLin Province and the Hi-Tech Progress Prize of JiLin Province twice.
1. Fan B, Wang JF, Zheng B, Qi XZ, Song JY, Li GY. Clinical features of 10 cases of eyelid sporotrichosis in Jilin Province (Northeast China). Can J Ophthalmol. 2016 Aug;51(4):297-301.
2.Fan B, Li FQ, Zuo L, Li GY. mTOR inhibition attenuates glucose deprivation-induced death in photoreceptors via suppressing a mitochondria-dependent apoptotic pathway.Neurochem Int. 2016 Oct;99:178-86.
3. Fan B, Li FQ, Song JY, Chen X, Li GY. Inhibition of mTOR signaling protects photoreceptor cells against serum deprivation by reducing oxidative stress and inducing G2/M cell cycle arrest. Mol Med Rep. 2016 May;13(5):3771-8.
4. Zhang TZ, Fan B, Chen X, Wang WJ, Jiao YY, Su GF, Li GY. Suppressing autophagy protects photoreceptor cells from light-induced injury.Biochem Biophys Res Commun. 2014 Jul 25;450(2):966-72
5. Li GY, Fan B, Jiao YY. Rapamycin attenuates visible light-induced injury in retinal photoreceptor cells via inhibiting endoplasmic reticulum stress.Brain Res. 2014 May 14;1563:1-12.
6.Li GY, Fan B, Jiao YY. Endonasal endoscopy for removing nasal chondromesenchymal hamartoma extending from the lacrimal sac region.Can J Ophthalmol. 2013 Apr;48(2):e22-3.
7. Li GY, Li T, Fan B, Zheng YC, Ma TH. The D₁ dopamine receptor agonist, SKF83959, attenuates hydrogen peroxide-induced injury in RGC-5 cells involving the extracellular signal-regulated kinase/p38 pathways.Mol Vis. 2012;18:2882-95.
8. Li GY, Fan B, Ma TH. Visible light may directly induce nuclear DNA damage triggering the death pathway in RGC-5 cells.Mol Vis. 2011;17:3279-89.
9. Li GY, Fan B, Zheng YC. Calcium overload is a critical step in programmed necrosis of ARPE-19 cells induced by high-concentration H₂O₂.Biomed Environ Sci. 2010 Oct;23(5):371-7.
10. Li GY, Fan B, Su GF. Acute energy reduction induces caspase-dependent apoptosis and activates p53 in retinal ganglion cells (RGC-5).Exp Eye Res. 2009 Oct;89(4):581-9.
11. Osborne NN, Li GY, Ji D, Andrade da Costa BL, Fawcett RJ, Kang KD, Rittenhouse KD. Expression of prostaglandin PGE2 receptors under conditions of aging and stress and the protective effect of the EP2 agonist butaprost on retinal ischemia. Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3238-48.
12. Costa BL, Fawcett R, Li GY, Safa R, Osborne NN.Orally administered epigallocatechin gallate attenuates light-induced photoreceptor damage.Brain Res Bull. 2008 Jul 1;76(4):412-23.
13. Osborne NN, Li GY, Ji D, Mortiboys HJ, Jackson S.Light affects mitochondria to cause apoptosis to cultured cells: possible relevance to ganglion cell death in certain optic neuropathies.J Neurochem. 2008 Jun;105(5):2013-28.
14. Li GY, Osborne NN. Oxidative-induced apoptosis to an immortalized ganglion cell line is caspase independent but involves the activation of poly(ADP-ribose)polymerase and apoptosis-inducing factor.Brain Res. 2008 Jan 10;1188:35-43.
15. Ji D, Li GY, Osborne NN. Nicotinamide attenuates retinal ischemia and light insults to neurones.Neurochem Int. 2008 Mar-Apr;52(4-5):786-98.